Abstract
The acyclic ligands with an adjacent bistetrahydrofuran (THF) skeleton have been synthesized as analogs of bullatacin, a representative natural product in a family of Annonaceous acetogenins, and their binding properties toward metal cations have been investigated. The dihydroxyl bis-THF ligands with alkyl chains showed specific binding toward Ca 2+, and those with acetamido groups exhibited potent binding with Ca 2+ and Mg 2+. The ligand with ether chains showed higher affinity toward Mg 2+. These binding properties which depend on the nature of side chains and their stereochemistry have been analyzed by molecular modeling.
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