Abstract
AbstractEthyl 3‐amino‐4,4,4‐trifluorocrotonate (3) has been converted by a one step reaction with alkyl and aryl isocyanates to novel 3‐substituted‐6‐(trifluoromethyI)uracils. Also several 3‐amino‐4,4,4‐trifluorocrotonitriles (11a‐c) have been cyclized to novel 6‐(trifluoromethyI)cytosines (13a‐c) and then hydrolyzed to the corresponding uracils (4, 14b‐c). Alkylation studies with isopropyl bromide of three 6‐(trifluoromethyl)uracils (1, 4, 5) are described.
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