Novel [1,3]-migration of methyl group in imidazo[4,5-c]quinoline

Abstract

Abstract In synthetic studies of imidazo[4,5- c ]quinolin-4(5 H )-one derivatives, which exhibit a potent antiasthmatic activity, an unusual rearrangement was observed, where the methyl group migrates from the N-1 to the N-3 position on the imidazole during the reaction of Chapman rearrangement of 1-methyl-4-phenoxy-1 H -imidazo[4,5- c ]quinoline 2 .