Novel 1,2,3,6-tetrahydropyridine derivatives with potent antihypoxic activity

Abstract

A number of 1,2,3,6-tetrahydropyridine derivatives 1a–u were synthesised. They were examined for their antihypoxic actions in mice and rats using various hypoxic tests ( eg, hypobaric hypoxia, cytotoxic hypoxia, and asphyxic anoxia). Some of the compounds described displayed significant antihypoxic activity. The antihypoxic activity of the most effective compound ( 1q) is propably unrelated to the hypothermising action. The participation of adrenergic and serotoninergic receptors in this effect can also be excluded. However, the activity of this compound may be related to the inhibition of cellular Ca 2+ movement.