Abstract
Bacterial infections are responsible for a third of all deaths worldwide. Then, the development of new bacterial vaccines is a significant challenge. The most of the available vaccines are composed of killed or attenuated whole cells. Such vaccines are not efficient for all and present important side effects. To overcome these limits, new vaccination approaches must be developed and new bacterial target must be identified. At the present time, several candidates for new vaccine were studies, such as polyosides, phosphorylcholine and surface membrane proteins (adhesins and toxins). These highly purified antigens share to the composition of new vaccines, so called « acellular å.
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