Abstract
The O,S-dimethylphosphorochloridate 10 reacts with 5′-O-monomethoxytritylthymidine 11 in pyridine giving nucleoside-3′-thiolophosphodiester 13 in high yields; in acetonitrile and in the presence of 1-methylimidazole, this reaction leads to the nucleoside-3′-phosphotriester 14 without formation of diester 13 . From the latter, the Tp and TpT have been prepared.
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