Notice of Retraction: Effects of Lead in Drinking Water on Biochemical Alterations in Multi-Organs of Mice

Abstract

The present study was conducted to investigate the effects of lead in drinking water on biochemical alterations in brain, liver and kidney of mice. The biochemical alterations and antioxidant enzymes in different treated mice were determined by commercial kits. The metal concentrations were measured using atomic absorption spectrophotometer (AAS). The results showed that lead acetate with different concentrations of 100, 200 and 300 mg/L, which could significantly increase GSH level and CAT activities, and lower the GSSG and TBARS level in brain, liver and kidney of mice. Furthermore, the changes of biochemical alterations and antioxidant enzymes had concentration-dependent relations. Brain SOD activity in different treated mice had obviously increase, which with the concentration-dependent manner. This study also suggested that lead concentration in blood, brain, liver and kidney of mice significantly increased after lead exposed in drinking water with different concentrations. Like the biochemical parameters, lead concentration in blood, brain, liver and kidney of different mice has obvious concentration-dependent relations. Compared with normal group, the percentage of increased blood lead level was 210-285%, brain lead level was 164-318%, liver lead level was 205-628% and kidney level was 424-816% in lead exposed mice, respectively. In conclusion, this study reported that lead acetate capable of causing marked oxidative damage in addition to inhibiting the activities of antioxidant enzymes with low level in developing mice. Furthermore, the changes of biochemical alterations had significant concentration-dependent manner.