Abstract
Traumatic spinal cord injury (tSCI) often leads to debilitating neurological disabilities that in addition to the loss of sensory and motor capabilities, also includes other issues with the bladder, heart and respiration. Overall, tSCI results in a drastic decrease in the quality of life. Traumatic spinal cord injury causes an almost complete loss of blood flow at the site of injury (primary injury) as well as significant ischemia surrounding the injury, resulting in progressive additional cell death over time (secondary injury). Counteracting secondary injury of spinal cord tissue surrounding tSCI is an active area of research to improve outcomes. There are no existing techniques to assess simultaneously both temporal and spatial changes in blood flow of contused spinal cord tissue in experimental settings. The goal of this work was to visualize temporal and spatial changes in blood flow following tSCI in a rat spinal cord injury model.
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