Abstract
The platelet adhesive index and calcium clotting time were investigated in 23 cases of multiple sclerosis before and after treatment with ACTH by intravenous infusion. It was found that in 60% of cases of multiple sclerosis platelet stickiness was higher than in normal controls and that the changes in platelet stickiness were related to activity of the pathological process. In most cases the pathologically-increased adhesiveness returned to normal after ACTH treatment. This does not, however, appear to be caused by a direct influence of ACTH. The investigation of the platelet adhesive index is of little or no diagnostic value, but it might prove useful in the assessment of the therapeutic effects of various drugs.
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