Note on the production of glycosuria by parathyroids, pancreas and the infundibular extract of the pituitary

Abstract

In experiments upon cats we have found that injection per jugular of filtered watery solution of the parathyroid or the pancreas produced 3 to 4 per cent. of sugar in the urine. Injections into abdominal cavity of the pancreas also produced glycosuria. Borchardt has shown that the pituitary gland as a whole causes sugar to appear in the urine. We have found 1 c.c. of the 20 per cent. extract of the infundibular part (Burroughs, Wellcome and Co.) of the pituitary by the jugular causes about 3 per cent, of sugar to appear in the urine. We took care that the binding down and etherization did not cause any sugar to be present in the urine of our animals. Falta and Priestly did not find any increase of the sugar in the blood of the rabbit by relatively large doses of infundibulin. The presence of glucose was always determined by Fehling's, fermentation, and phenylhydrazine tests.