Abstract
Small cell lung cancer (SCLC) is highly heterogeneous. In this issue of Cancer Cell, Ireland etal. demonstrate that MYC mediates neuroendocrine cell plasticity in SCLC by activating NOTCH signaling. This MYC-NOTCH axis controls the dynamic behavior of tumor cells, resulting in the co-existence of SCLC subtypes within individual tumors.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have