Abstract
The Notch signaling pathway is highly evolutionarily conserved, dictating cell fate decisions and influencing the survival and growth of progenitor cells that give rise to the cells of the immune system. The roles of Notch signaling in hematopoietic stem cell maintenance and in specification of T lineage cells have been well-described. Notch signaling also plays important roles in B cells. In particular, it is required for specification of marginal zone type B cells, but Notch signaling is also important in other stages of B cell development and activation. This review will focus on established and new roles of Notch signaling during B lymphocyte lineage commitment and describe the function of Notch within mature B cells involved in immune responses.
Highlights
Edited by: Zhenming Xu, The University of Texas Health Science Center at San Antonio, United States
The intracellular region of Notch receptors is comprised of a RBP-Jk association module (RAM) domain, seven ankyrin (ANK) repeats flanked by two nuclear localization signals, a transactivation domain (TAD), and a proline/glutamic acid/serine/
Exposure of cultured human hematopoietic progenitors to Notch ligands Dll1 or Dll4 inhibits their differentiation to the B cell lineage, exposure to Notch ligand Jg1 does not inhibit B cell differentiation [48, 49]. These results suggest that Notch signaling in the bone marrow environment has the potential to block B cell development from precursor cells (Figure 4)
Summary
Edited by: Zhenming Xu, The University of Texas Health Science Center at San Antonio, United States. Notch Signaling in B Cell Immune Responses. The roles of Notch signaling in hematopoietic stem cell maintenance and in specification of T lineage cells have been well-described. Notch signaling plays important roles in B cells. It is required for specification of marginal zone type B cells, but Notch signaling is important in other stages of B cell development and activation. This review will focus on established and new roles of Notch signaling during B lymphocyte lineage commitment and describe the function of Notch within mature B cells involved in immune responses
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