Abstract
A brute-force approach has been used to address a classic problem in cell biology--how cell growth and the cell division cycle are coordinated so that cells maintain a certain size. Jorgensen et al. (see the Perspective by Sudbery) performed a systematic analysis of the complete set of yeast haploid deletion strains that yielded strains (several thousand) that were either larger or smaller than their normal counterparts. Further genetic analysis revealed a dozen new regulators of Start, the point in the yeast cell cycle at which the cell commits to a new round of cell division. The groups of genes identified point to a key role of nucleolar genes and genes affecting ribosome biogenesis in control of cell size, as well as cell growth. P. Jorgensen, J. L. Nishikawa, B.-J. Breitkreutz, M. Tyers, Systematic identification of pathways that couple cell growth and division in yeast, Science 297 , 395-400 (2002). [Abstract] [Full Text] P. Sudbery, When Wee meets Whi, Science 297 , 351-352 (2002). [Summary] [Full Text]
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