Abstract
Researchers at Okayama University, Japan showed lactate dehydrogenase (LDH) inhibition suppresses neuronal excitation in vitro, reduces EEG discharges and seizures in rodent models, and may provide a novel mechanism for anticonvulsant medications in human patients.
Highlights
The authors report two important new findings: (1) the neuronal inhibition associated with the KD correlate with reduced pyruvate and oxaloacetate levels, and (2) LDH inhibitors that lower pyruvate and oxaloacetate levels work as anticonvulsants in vitro and in vivo models
It’s easier to imagine using LDH inhibitors to enhance the action of the ketogenic diet than to replace it
Many hypotheses have been proposed for the anticonvulsant mechanism of the ketogenic diet
Summary
The authors report two important new findings: (1) the neuronal inhibition associated with the KD correlate with reduced pyruvate and oxaloacetate levels, and (2) LDH inhibitors that lower pyruvate and oxaloacetate levels work as anticonvulsants in vitro and in vivo models. KD and LDH inhibitors have an important difference: LDH inhibitors do not provide an alternative fuel to make up for the lost pyruvate and oxaloacetate.
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