Abstract
Cell adhesion is fundamental for multicellular life. Many physiological processes, including organism development, wound healing, and the immune response, depend on the cells’ ability to form delicate, adaptive attachment sites connecting them mechanically to their environment. Over the past decades, we have learned that cells are, in situ, highly sensitive to geometrical constraints (1,2,3) and the mechanical rigidity of their microenvironment (4,5,6). For example, in vitro experiments, during which cells are placed on micropatterned substrates, revealed that edges and corners in the patterns promote formation of contractile cytoskeletal structures (3).
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