Abstract
BackgroundThe spread and outbreak of Enterobacteriaceae producing OXA-48-like carbapenemases have become more and more prevalent in China.ResultsA total of 62 non-duplicated OXA-232-producing K. pneumoniae (OXA232Kp) were isolated between 2015 and 2017. An outbreak of OXA232Kp was observed in burn ICU. The 62 OXA232Kp isolates were all belongs to ST15 and categorized into two PFGE types (A and B). Type A was dominated of the isolates, which contained 61 clinical isolates and divided into 10 subtypes (A1-A10). In addition, most of OXA232Kp strains exhibited low-level carbapenems resistance. All strains carried a 6141 bp ColKP3 plasmid harboring the blaOXA-232 gene which is highly homologous to other blaOXA-232-bearing plasmids involved in other studies in eastern China.ConclusionsIn this study, clone transmission of OXA232Kp ST15was observed. Highly significant homology among the blaOXA-232-bearing plasmids indicated the important role of the 6.1 kb ColE-like plasmid on the prevalence of blaOXA-232 gene in China.
Highlights
The spread and outbreak of Enterobacteriaceae producing OXA-48-like carbapenemases have become more and more prevalent in China
We reported a nosocomial outbreak of OXA232Kp in a teaching hospital in Shanghai involved with 61 patients
Emergence and outbreak of OXA232Kp A total of 141 non-duplicated K. pneumoniae isolates that exhibited non-susceptibility to carbapenems were recovered from various clinical specimens between 2015 and 2017
Summary
The spread and outbreak of Enterobacteriaceae producing OXA-48-like carbapenemases have become more and more prevalent in China. Carbapenem resistance in Enterobacteriaceae is usually attributed to the production of various carbapenemases, a set of enzymes that lead to the hydrolysis of beta-lactams [1]. OXA-48, a novel class D carbapenemase, was identified in a clinical Klebsiella pneumoniae isolate in 2004 [2]. OXA-48producing Enterobacteriaceae has been reported worldwide [3]. OXA-48 and its several variants have been identified in Enterobacteriaceae. These variants are one to five amino acid substitutions differs from OXA-48 [3, 4]. Most of OXA-48-type carbapenemases hydrolyze carbapenems slightly, while some OXA-48-like variants (such as OXA-163, OXA-247 and OXA-405) only
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