Abstract
Background & aims: Hepatitis C virus infection is characterized by its association with several autoimmune disorders. Chronic hepatitis C (CHC) patients display increased amount of T helper 17 (Th17) cells. Th17 are involved in both liver inflammation and autoimmunity. In CHC patients, serum levels of oxysterols, the specific ligands of Liver X Receptors (LXRs) and non-enzymatic cholesterol oxo-derivatives molecules, are higher than in non-alcoholic fatty liver disease (NAFLD) patients. Interestingly, LXR activity influences the differentiation of Th17 cells; besides Hepatitis C virus direct interferes with the activity of LXR/RXR heterodimer.
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