Abstract
Methods Healthy males from the University of Oxford (n = 12, age 24 ± 2) underwent twenty hours of normobaric hypoxia in purpose-built hypoxia chambers. The partial pressure of oxygen during end tidal expiration (PETO2) was kept between 50 and 60 mmHg, whilst keeping peripheral oxygen saturation (SaO2) above 80%. Cardiac function was measured using magnetic resonance imaging (MRI) and echocardiography. High-energy phosphate metabolism was measured as the ratio of phosphocreatine to ATP (PCr/ATP) by 31Phosphorus magnetic resonance spectroscopy (MRS) before and after twenty hours of hypoxia. Additionally, four subjects had blood taken for biochemical analysis every four hours.
Highlights
In the first few days of hypoxic exposure, left ventricular dysfunction is consistently observed in human heart, yet the cellular mechanisms underlying the dysfunction are poorly understood
Abstracts of the 13th Annual SCMR Scientific Sessions - 2010 Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1532-429X-11-S1-info
High-energy phosphate metabolism was measured as the ratio of phosphocreatine to ATP (PCr/ATP) by 31Phosphorus magnetic resonance spectroscopy (MRS) before and after twenty hours of hypoxia
Summary
Cameron J Holloway*1, Lowri E Cochlin, Ion Codreanu, Edward Bloch, Marzieh Fatemianl, Cezary Szmigielski, Andrew Johnson, Jane M Francis, Peter Robbins, Stefan Neubauer and Kieran Clarke. Address: 1University of Oxford, Oxford, UK and 2The University of Oxford, Oxford, UK * Corresponding author from 13th Annual SCMR Scientific Sessions Phoenix, AZ, USA. Published: 21 January 2010 Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):O18 doi:10.1186/1532-429X-12-S1-O18. Abstracts of the 13th Annual SCMR Scientific Sessions - 2010 Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1532-429X-11-S1-info
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