Normative values of event-related potentials (erps) for children in manado, Indonesia

Abstract

Introduction Event-related potentials (ERPs) are objective electrophysiological measuring instruments for cognitive function. The ERPs normative values have never been determined in children of our local population. We want to determine the normative values of ERPs for children in Manado, Indonesia. Methods A cross-sectional study examining auditory ERPs in 88 children from Manado. The eligibility criteria were healthy children aged 8 to 12 years old. Cognitive function was screened using pediatric mini-mental state examination. Subjects should have enough sleep before the examination. The values were assessed using Natus DantecTMKeypoint® Focus 6 channels machine. The results were read by an expert examiner. The median and interquartile range were used to describe the normative data across five age groups. Examined variables were the median latency and amplitude of ERPs components (N100, N200, and P300) and motor performance (reaction time, hits, omission error, and commission error). These variables were analyzed for between-group difference (age and sex). Results Median latency values of P300 at Fz, Cz, Pz, and combined leads for the youngest and the oldest ages were as follow: 347ms, 402ms, 346ms, and 373.3ms on 8 years old subjects and 394ms, 303ms, 385ms, and 362ms on 12 years old subjects. There was no significant between-group difference for age groups and sex. Conclusion We have determined the normative values of ERPs for children in Manado.