Abstract
The study aimed to present the normative information of cortical gray matter thickness and subcortical volumes of the brain in the Korean elderly. We measured cortical gray matter thickness and subcortical volumes from anatomical MRI scans of 681 cognitively normal participants aged 65 to 80 using FreeSurfer. General linear model analyses were performed with age as the independent variable and region of interest measures as the dependent variable. Gender and education level were added into the models as covariates since they are considered as potential confounding variables on evaluating the relationship between brain measures and age. Beta coefficient estimates of age were estimated at each cortical vertex and subcortical structure. Among the four lobes, the temporal lobe, particularly the entorhinal cortex, showed the most rapid decay with age (min(beta) = - 0.02 mm per year). Mean and standard deviation also were calculated. This normative model of the aging brain provides the age-related reference ranges needed to facilitate research and clinical decision making such as diagnosis of neurodegenerative diseases.
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