Abstract
Objective: The aim of this study was to gather data on the importance of chitotriosidase in the prediction of abortion by comparing maternal serum chitotriosidase activity in normal pregnancies and in abortions. Material and Methods: This study was designed as a prospective case-control study and included 142 pregnancies; 81 ended with abortion before 10 weeks of gestation, and 61 normal pregnancies. Five women in the spontaneous abortion group and one woman in the normal pregnancy group were excluded from the study. Peripheral blood samples were obtained from all pregnant women. Chitotriosidase activity was studied in these samples using the fluorometric method. Results: Chitotriosidase activity was significantly higher in the spontaneous abortion group compared to the control group (p<0.01). A threshold of 46 nmol/mL/hour for maternal chitotriosidase activity yielded 53.9% sensitivity and 85% specificity. There was no significant difference between the type of abortion and chitotriosidase activity (p>0.05). Conclusion: Activated macrophages may play a role in the pathogenesis of abortion. Further studies are warranted on this subject. This is the first study evaluating macrophage activation in spontaneous abortion.
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