Abstract
The major generalisations about the inheritance of fatness in ‘normal’ mice are: (1) Mice selected for high growth rate become very fat as adults. (2) There are heritable differences between strains of mice in their propensity for fattening at the same stage of development. The possible contribution of changes in metabolic and behavioural traits to these two types of heritable variation is discussed. It would seem that differences of the first type result from an excessive appetite and a relatively lower maintenance cost. The causation of differences among strains in their ability to partition energy between fat and lean tissues at the same stage of development is less well understood but such differences can be generated by different types of selection for growth rate.
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