Abstract
BackgroundThe objective of this study was to establish age-dependent values for urinary renalase/creatinine (renalase/Cr) ratio in healthy children and adolescents.MethodsThe study was conducted on a random sample of 157 healthy children and adolescents (0.1–17.9 years) divided into six age groups in 3-year intervals. Urine renalase concentration was measured using an enzyme-linked immunosorbent assay (ELISA) kit (Uscn Life Science, Wuhan, China).ResultsWe analyzed median urine renalase/Cr ratio in particular age groups with the use of analysis of variance (ANOVA). Renalase/Cr levels were significantly higher in the youngest children < 3 years in comparison with other age groups (4.07 ng/mg Cr, p < 0.05). There was a statistically significant negative correlation between urine renalase/Cr and body mass index (BMI) Z-score (r = −0.22, p < 0.05) and both systolic (r = −0.22, p < 0.05) and diastolic (r = −0.21, p < 0.05) blood pressure. We constructed the reference renalase/Cr percentiles according to age in 3-year intervals.ConclusionsTo the best of our knowledge, this study is the first to present reference values of urine renalase excretion in a healthy pediatric population. Further studies should concentrate on the influence of increased blood pressure or obesity on urine renalase excretion in children and teenagers.
Highlights
Renalase is a flavin adenine dinucleotide-dependent (FADdependent) hormone belonging to the amino-oxidase family that was recently identified by Xu et al [1]
The study group of 157 individuals was divided into six age groups in 3-year intervals: 0.1–2.9, 3–5.9, 6–8.9, 9–11.9, 12– 14.9, and 15–18 years old; 50.3 % were and 49.7 % boys of similar age (p>0.05)
The highest values were found in the youngest children (0.1–2.9 years), and we observed a decrease in renalase urine concentration with age
Summary
Renalase is a flavin adenine dinucleotide-dependent (FADdependent) hormone belonging to the amino-oxidase family that was recently identified by Xu et al [1]. It is secreted into the blood by the kidney but is found in heart, skeletal muscles, small intestine, and liver. Renalase can be detected in plasma or urine by Western blotting. Detection of renalase in blood and urine suggests its production by renal tissue, and undetectable levels of the enzyme in the plasma of patients with uremia confirm this hypothesis [1, 2]. The aim of this study was to establish agedependent values for urinary renalase concentration in healthy children and adolescents. The objective of this study was to establish agedependent values for urinary renalase/creatinine (renalase/Cr) ratio in healthy children and adolescents
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