Abstract
Objective: This study aims to document the sperm DNA damage results in infertile male patients with normal-standard semen parameters retrospectively.Material and Methods: The study included samples from 500 male patients with a referred diagnosis of idiopathic infertility and a medical history of at least one assisted reproductive technique (ART) failure. All the patients included in this study were otherwise healthy individuals and had normal-standard semen parameters. We performed retrospective analysis, from the results obtained from samples. Tunel methodology was used, and fluorescence microscopy analysis was performed. From a morphological point of view, apparently normal mature sperms were analyzed. Results: Increased sperm DNA damage rates were detected in our tested population. Advanced age did not correlate with a significant increase in sperm DNA damage ratios in our cohort.Conclusion: The importance of sperm DNA damage should be considered as an etiological factor when evaluating infertile couples. Because the ratio of DNA damage might correlate with various indicators of fertility such as the fertilization rate, embryo cleavage rate, implantation rate, pregnancy rate and live birth rate, it is important to know the ratio of spermatozoa with damaged DNA in the ejaculate in order to predict the fertilization rate and determine the risks that may affect the embryo.
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