Abstract
TLC separation of the UV filters avobenzone (AVO) and octocrylene (OCR) on RP-18 and silica gel 60 as stationary phases, with numerous mobile phases, revealed that these compounds have similar retention properties under almost all the chromatographic conditions investigated. Analysis of avobenzone in the presence of octocrylene may be achieved on silica gel 60 with cyclohexane-diethyl ether 1:1 (ν/ν) as mobile phase, at the selective wavelength 380 nm, at which octocrylene does not absorb (Method A). Analysis of octocrylene in the presence of avobenzone by the same method was, however, impossible because of insufficient chromatographic separation of AVO and OCR and overlap of the absorption ranges of AVO and OCR (with OCR peaks being obscured by those of AVO). An alternative separation strategy was proposed that proved successful for OCR in the presence of AVO. This involved chromatography on silica gel 60 with cyclohexane-piperidine 15:1 (ν/ν) as mobile phase (Method B). When these chromatographic condit...
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