Normal memory recovery by activation of 5-HT4 receptors in hippocampal lesioned and normal aged rats

Abstract

Event Abstract Back to Event Normal memory recovery by activation of 5-HT4 receptors in hippocampal lesioned and normal aged rats Evelyne Marchetti1*, Marlyse Jacquet1, Helene Jeltsh2, Martine Migliorati1, Emmanuel Nivet1, Jean-Christophe Cassel2 and Francois S. Roman1 1 Universite de Provence, Laboratoire de Neurobiologie des Processus Mnesiques, France 2 Universite Louis Pasteur, Laboratoire d-Imagerie et de Neurosciences Cognitives, France Colchicine lesions induced a substantial loss of granule cells and damage to the overlying pyramidal cell layer in region CA1 in adult male Long-Evans rats. All rats with such lesions showed a significant associative learning deficit in an olfactory discrimination task, while being unimpaired in the procedural component of this task. Injection of a partial selective 5-HT4 agonist (SL65.0155 ; 0.01 mg/kg, i.p.,vs.saline) before the third of six training sessions enabled complete recovery of associative learning performance in the lesioned rats. In the same way this specific agonist improved memory performance in the same task in aged rats. Activation of 5-HT4 receptors by a selective agonist such as SL65.0155 might therefore provide an opportunity to reduce learning and memory deficits associated with temporal lobe damage, and could be useful for the symptomatic treatment of memory dysfunctions related to normal an pathological aging such as Alzheimer's disease. Conference: 41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009. Presentation Type: Poster Presentation Topic: Poster presentations Citation: Marchetti E, Jacquet M, Jeltsh H, Migliorati M, Nivet E, Cassel J and Roman FS (2009). Normal memory recovery by activation of 5-HT4 receptors in hippocampal lesioned and normal aged rats. Conference Abstract: 41st European Brain and Behaviour Society Meeting. doi: 10.3389/conf.neuro.08.2009.09.223 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 11 Jun 2009; Published Online: 11 Jun 2009. * Correspondence: Evelyne Marchetti, Universite de Provence, Laboratoire de Neurobiologie des Processus Mnesiques, 13331 Marseille, France, evelyne.marchetti-gauthier@univ-provence.fr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Evelyne Marchetti Marlyse Jacquet Helene Jeltsh Martine Migliorati Emmanuel Nivet Jean-Christophe Cassel Francois S Roman Google Evelyne Marchetti Marlyse Jacquet Helene Jeltsh Martine Migliorati Emmanuel Nivet Jean-Christophe Cassel Francois S Roman Google Scholar Evelyne Marchetti Marlyse Jacquet Helene Jeltsh Martine Migliorati Emmanuel Nivet Jean-Christophe Cassel Francois S Roman PubMed Evelyne Marchetti Marlyse Jacquet Helene Jeltsh Martine Migliorati Emmanuel Nivet Jean-Christophe Cassel Francois S Roman Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.