Normal Development of Local Neurovascular Interactions and the Diagnostic Value of Resting State Functional MRI in Neurovascular Deficiency Based on the Example of Neonatal Anesthesia Exposure.

Daniil P Aksenov

doi:10.3389/fneur.2021.664706

Abstract

Normal Development of Local Neurovascular Interactions and the Diagnostic Value of Resting State Functional MRI in Neurovascular Deficiency Based on the Example of Neonatal Anesthesia Exposure.

Highlights

Anesthesia-induced learning deficiency is a serious problem in pediatrics
A larger concentration of a general anesthetic can greatly decrease or even completely abolish BOLD functional MRI (fMRI) signal [40]. It seems that this effect might depend on the type of general anesthetic because, for example, the level of suppression of neuronal activity is very different under 1 MAC of sevoflurane and 1 MAC of isoflurane [41]
Of resting state fMRI (rsfMRI) mechanisms, neuronal synchronization can induce an additional factor of correlation between rsfMRI and neuronal activity because both the oxygen delivery and consumption curves may be synchronized with simultaneous firing of multiple neurons

Summary

Introduction

Anesthesia-induced learning deficiency is a serious problem in pediatrics. it is not clear which instrumental methods can be used for the evaluation of anesthesia-induced toxicity and for the prediction of behavioral and learning deficiencies. We discuss the diagnostic and prognostic role of resting state fMRI and possible mechanisms which are responsible for anesthesia-induced neurovascular deficiency. We suggest that neonatal widespread apoptotic neurodegeneration should affect further development, as a manifestation of deficiency in neurovascular interactions, and this effect can be visualized using functional MRI (fMRI).

Results

Conclusion