Abstract
Growth hormone deficiency is a frequent consequence of external cranial radiation. Retinoblastoma is a particular situation with radiation ( 3500 rads) performed before age of 4 yr. 30 prepubertal children were studied with a follow-up of 5-14 yr. In group I, 8 were GH deficient with low SM activity. In group I (GH and SM deficiency) mean bone age (BA) was slightly retarded (BA/CA), but not different from the mean value in group II (normal GH response to arginineinsulin AITT and slightly diminished SM activity). In conclusion, GH and SM deficiency were found in only 26 % of the patients. Bone maturation was normal or slightly delayed (as in the control group II). This could be due to a late appearence of pituitary dysfunction or to a particular still unexplained, situation due to the early age at radiation.
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