Abstract

With the dramatic increase of interest aimed at manipulating and transplanting normal human stem cells for clinical applications and for purging or eradicating leukemic stem cells, there is great need for in vivo assays for normal and leukemic human stem cells. The recent development of methods to transplant human hematopoietic cells into immune-deficient mice provides an important approach to characterize stem cells and to develop animal models for hematopoietic diseases including leukemia

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