Abstract

Fresh liver homogenates from male mice previously treated with steroids were assayed for Phosphorylase activity and glycogen content. One hour following the injection of norethandrolone (2.0 mg./Kg.), significant decreases in liver glycogen and liver Phosphorylase activity were noted. Lower doses of norethandrolone (0.5 and 1.0 mg./Kg.) produced only moderate reductions in enzymatic activity. Norethynodrel (2.0 mg./Kg.) was also observed to reduce liver glycogen and liver Phosphorylase activity. Ethisterone and testosterone (2.0 mg./Kg.) caused slight alterations in enzymatic activity, but liver glycogen remained essentially unchanged. Cortisone administration (2.0 mg./Kg.) resulted in diminished enzymatic activity, but enhanced liver glycogen.

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