Abstract
The present study determined whether [ 3H]nisoxetine binding to norepinephrine transporter sites would be altered uniformly througout the locus coeruleus in Alzheimer's disease. A significant decrease ( P < 0.01) in [ 3H]nisoxetine binding was seen in the mid and caudal regions but not in the rostral region of the locus coeruleus. The loss of [ 3H]nisoxetine binding to norepinephrine transporter sites may be attributed to a loss of norepinephrine transporter sites located on terminals of noradrenergic neurons in the locus coeruleus in Alzheimer's disease.
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