Abstract
We examined whether norepinephrine (NE) had direct effects on cytokine production by murine intestinal intraepithelial lymphocytes (IELs), compared with splenocytes. CD3+ IELs and CD3+ splenocytes expressed α1B, α1D, α2C, β1, β2, and β3 adrenoceptors (ARs). NE significantly suppressed IFN-γ and TNF-α production by IELs and splenocytes ex vivo. The suppressive effects of NE in IELs were reversed by β1 AR antagonist CGP-20712A, whereas those in splenocytes were reversed by β2 AR antagonist ICI118,551. In IELs, β1 AR agonist xamoterol mimicked the suppressive effects of NE. These results indicated NE regulates intestinal mucosal immune responses mediated by IELs via β1 AR.
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