Abstract
Norepinephrine N-methyltransferase (NMT, EC 2.1.1.28), the terminal enzyme in epinephrine biosynthesis, catalyzes the transfer of the labile methyl group from S-adenosyl-L-methionine (SAMe) to norepinephrine. The richest source of NMT is the adrenal medulla, quantitatively the most important site of epinephrine production in mammalian species. This enzyme is also present in brain in discrete neurons that apparently make and use epinephrine as their neurotransmitter substance (Hokfelt et al, 1974). Since NMT is the only enzyme unique to epinephrine biosynthesis, it has become a focus of study in recent years for those interested in epinephrine-forming neurons and their functions in brain. Inhibitors of NMT would reduce neurotransmitter synthesis in epinephrine-forming neurons in brain without directly affecting other neurons that use dopamine or norepinephrine as their transmitter. Thus NMT inhibitors are potentially useful tools for pharmacologic modification of the epinephrine-forming neurons in brain.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.