Noradrenergic modulation of tactile responses in rat cortex. Current source-density and unit analyses

Abstract

This study describes the noradrenergic modulation of tactile afferent information in the sensorimotor cortex of urethane-anesthetized rats. Synaptic and spike responses to a mechanical stimulation of the hand palm were evaluated by means of current source-density analysis and unit activity recording in all cortical layers. Results showed that activation of the locus coeruleus decreased and shortened afferent synaptic excitation in supragranular, but not in deep layers. On the average, unit responses exhibited facilitated latency, moderately increased amplitude, enhanced postexcitatory inhibition and synchronization of responses across layers. The apparent paradox of this global phasic facilitation correlated with a decrease in input synaptic currents was discussed according to hypotheses which might explain its functional significance.