Abstract
Neuromodulation in sensory perception serves important functions such as regulation of signal to noise ratio, attention, and modulation of learning and memory. Neuromodulators in specific sensory areas often have highly similar cellular, but distinct behavioral effects. To address this issue, we here review the function and role of two neuromodulators, acetylcholine (Ach) and noradrenaline (NE) for olfactory sensory processing in the adult main olfactory bulb. We first describe specific bulbar sensory computations, review cellular effects of each modulator and then address their specific roles in bulbar sensory processing. We finally put these data in a behavioral and computational perspective.
Highlights
Neuromodulators such as noradrenaline (NE), acetylcholine (ACh) and serotonin (5HT) serve important functions in sensory perception
We here review the role and function of two major neuromodulators, ACh and NE, for modulation of early olfactory perception; we focus our discussion on the olfactory bulb
Central and modulatory inputs to primary sensory structures allow for flexibility and regulation of sensory processing according to behavioral demands
Summary
New York University School of Medicine, USA Sebastien Bouret, Institut du Cerveau et de la Moelle Epiniere, France. Neuromodulators in specific sensory areas often have highly similar cellular, but distinct behavioral effects. To address this issue, we here review the function and role of two neuromodulators, acetylcholine (Ach) and noradrenaline (NE) for olfactory sensory processing in the adult main olfactory bulb. We first describe specific bulbar sensory computations, review cellular effects of each modulator and address their specific roles in bulbar sensory processing. We put these data in a behavioral and computational perspective
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