Abstract
Medicinal products of nootropic action, which have a positive effect on neurometabolism and normalize memory and intellectual functions, are an important component of complex pharmacotherapy for various neurological and cerebrovascular diseases. The aim of the work was an experimental study of the nootropic activity of the new combined drug Melarginin, which includes 3-(2,2,2-trimethylhydrazinium) propionate (meldonium), L-arginine, and inosine in a fixed ratio. In experiments on female Balb/c mice, it was established that Melarginin in doses of 250 and 500 mg/kg (per os for 14 days) statistically significantly increased the survival of animals in acute hypoxia, in a dose of 250 mg/kg - contributed to the preservation of cognitive function in experimental amnesia, improved spatial memory and recognition of the new location of the object, and in a dose of 500 mg/kg - increased muscle tone and endurance to physical and psychoemotional stress. The revealed effects indicate a nootropic effect due to the combined cyto- and cerebroprotective properties of the studied combined agent components. Based on the obtained data, the new pharmacological combination can be a promising drug for neurological recovery and improvement of physical and mental performance in chronic cerebrovascular pathology. Keywords: combined drug Melarginin, hypoxia, amnesia, nootropic activity.
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