Abstract
Aim. Nootropic effects of bis(citrato)germanates (stannates) with different metals (Mg, Co) have been investigated in this article. With this aim the peculiarities of conditioned reflex formation as well as short- and long-term memory manifestations under the influence of the investigated coordinative compounds have been studied for 256 rats with the help of pathophysiological and pharmacological methods.Methods and results. It has been shown that stannates influence on the development of active avoidance conditioned reflex as well as on the manifestations of mnestic functions. It has been found that germacit and gercocit induce positive nootropic effects that occur in case of low dose drugs administration and are characterized by relief of conditioned reflex formation and by short- and long-term memory improvement at the same time.Conclusion. Stanmacit and stancocit also have nootropic effects that dependent on dose and are characterized by nootropic effect during administration in low doses and by amnestic effect at doses starting from 1/40 LD50. This indicates that stannates show nootropic activity.
Highlights
З метою дослідження ноотропних ефектів нових координаційних сполук – різнометальних (Mg, Co) бісцитратогерманатів – у 256 щурів вивчили особливості процесів формування умовного рефлексу, а також проявів коротко- і довгострокової пам’яті під їхнім впливом
It has been found that germacit and gercocit induce positive nootropic effects that occur in case of low dose drugs administration and are characterized by relief of conditioned reflex formation and by short- and long-term memory improvement at the same time
Stanmacit and stancocit have nootropic effects that dependent on dose and are characterized by nootropic effect during administration in low doses and by amnestic effect at doses starting from 1/40 LD50
Summary
It has been shown that stannates influence on the development of active avoidance conditioned reflex as well as on the manifestations of mnestic functions. It has been found that germacit and gercocit induce positive nootropic effects that occur in case of low dose drugs administration and are characterized by relief of conditioned reflex formation and by short- and long-term memory improvement at the same time
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