Abstract
In the present study, influence of the complex use of concentrate of polyunsaturated fatty acid (PUFA) from a fat of Baikal seal and cortexin on cognitive functions in rats with cerebral ischemia was evaluated. Cognitive impairments are early signs of cerebrovascular insufficiency, which are based on the development of pathobiochemical reactions that cause damage to the lipid and protein structures of cell membranes. It has been suggested that the administration of PUFA and cortexin will have a nootropic effect due to the synergy of their actions. The aim of the study was to determine the effect of PUFA and Cortexin on cognitive function in rats with cerebral ischemia. The study was performed on Wistar rats of both sexes. A model of cerebral ischemia was reproduced by occlusion of the left common carotid artery under ether anesthesia. Animals received PUFA (20 mg/kg) intragastrically once day for 14 days before surgery and for the next 10 days after in combination with administration of cortexin (4 mg/kg, i.p). For a comparative evaluation of the therapeutic efficacy of the complex use of PUFA and cortexin, three groups of animals were used: piracetam and monotherapy with PUFA, and Cortexin. Behavioral activity and cognitive functions in rats were determined using the methods: open field, elevated plus maze, Morris water maze. It has been established that combined use of PUFA and Cortexin stimulated locomotor and exploratory activity, reduced anxiety in animals and had a more effective nootropic effect as compared with monotherapy.
Highlights
Проведена оценка влияния комплексного применения концентрата полиненасыщенных жирных кислот из жира байкальской нерпы и Кортексина на когнитивные функции у крыс с ишемией головного мозга
Cognitive impairments are early signs of cerebrovascular insufficiency, which are based on the development of pathobiochemical reactions that cause damage to the lipid and protein structures of cell membranes
It has been suggested that the administration of polyunsaturated fatty acid (PUFA) and cortexin will have a nootropic effect due to the synergy of their actions
Summary
Исследования проводили на крысах линии Вистар обоего пола с массой 180–220 г согласно правилам, принятым на Европейской конвенции о защите позвоночных животных, используемых в экспериментальных и иных научных целях, в соответствии с Приказом МЗ РФ No 267 от 19.06.2003 «Об утверждении правил лабораторной практики».
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