Nootropic activity of ethanolic extract of Alangium salvifolium leaves on Scopolamine mouse model of Alzheimer's disease

Abstract

Background: Alangium salvifolium possesses completely different medicine activities such as antioxidant, anticancer, anti-inflammatory, bactericide, antifungal, and antifertility. It is also employed in the treatment of anxiety. The previous study is revealed significant of antidepressant activity of ethanolic extract of leaves of A. salvifolium (EASL) by stress-induced depression through forced swim test and tail suspension test models in Swiss albino mice. Aims and Objectives: The present study was designed to explore learning and memory enhancing activity leaves of A. salvifolium in Swiss albino mice. Materials and Methods: EASL of two divided doses (EASL-100 and 250 mg/kg orally) and scopolamine (0.4 mg/kg i.p.) per kg body weight was administrated for 7 days to individual groups of mice. The sensitivity behavioral models such as Elevated plus maze and Morris water maze were used to appraise learning and memory. However, scopolamine is the natural agent that is elicited cognitive state served as interoceptive models. The results area unit expressed as mean ± S.E.M. Statistical analysis was done by one-way analysis of variance test followed by Dunnett’s multiple comparison tests. P < 0.05 was measured as statistically significant. Results: The results of this study showed that Alangium salvifolium at the doses of 100–250 mg/kg significantly (P < 0.05) improved abstraction short-term and memory, the exceptional reduction in transfer latency of the 6th and 7th days as a region of learning and memory. Within the elevated maze and reducing the escape latency within the Morris water maze. Conclusion: The results concluded, leaves of A. salvifolium have revealed as a significant memory enhancing activity altogether the screening models used.