Abstract
Nonwoven textiles are used extensively in the field of medicine, including wound healing, but these textiles are mostly from conventional nondegradable materials, e.g., cotton or synthetic polymers such as polypropylene. Therefore, we aimed to develop nonwoven textiles from hyaluronan (HA), a biocompatible, biodegradable and nontoxic polysaccharide naturally present in the human body. For this purpose, we used a process based on wet spinning HA into a nonstationary coagulation bath combined with the wet-laid textile technology. The obtained HA nonwoven textiles are soft, flexible and paper like. Their mechanical properties, handling and hydration depend on the microscale fibre structure, which is tuneable by selected process parameters. Cell viability testing on two relevant cell lines (3T3, HaCaT) demonstrated that the textiles are not cytotoxic, while the monocyte activation test ruled out pyrogenicity. Biocompatibility, biodegradability and their high capacity for moisture absorption make HA nonwoven textiles a promising material for applications in the field of wound healing, both for topical and internal use. The beneficial effect of HA in the process of wound healing is well known and the form of a nonwoven textile should enable convenient handling and application to various types of wounds.
Highlights
Nonwoven textiles are porous layers formed from randomly oriented fibres of various diameters and lengths
If we look at HA derivatives, nonwoven textiles from the total benzoyl esters of HA were developed [15] and proposed as scaffolds for tissue engineering, but such materials are not suitable for wound-healing applications due to the high degree of HA
We present nonwoven textiles composed solely from unmodified HA as a promising material for applications in the field of wound healing
Summary
Nonwoven textiles are porous layers formed from randomly oriented fibres of various diameters and lengths. There has been a growing interest in the development of functionalized nonwoven wound dressings, e.g., with antibacterial properties [2,3,4] or with components that promote wound healing [5]. These wound dressings are still based on classical nondegradable textiles (e.g., cotton or synthetic polymers such as polypropylene). Hyaluronan (HA) is an anionic, nonsulphated linear polysaccharide that is naturally present in the human body and is biocompatible, biodegradable and nontoxic
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