Abstract
Wound healing poses a serious therapeutic problem. Methods which accelerate tissue regeneration and minimize or eliminate complications are constantly being sought. This paper is aimed at evaluation of the potential use of biodegradable polymer nonwovens releasing propolis as wound healing dressings, based on the literature data. Propolis is honeybee product with antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, analgesic, and regenerative properties. Controlled release of this substance throughout the healing should promote healing process, reduce the risk of wound infection, and improve aesthetic effect. The use of biodegradable aliphatic polyesters and polyester carbonates as a propolis carrier eliminates the problem of local drug administration and dressing changes. Well-known degradation processes and kinetics of the active substance release allows the selection of the material composition appropriate to the therapy. The electrospinning method allows the production of nonwovens that protect the wound against mechanical damage. Moreover, this processing technique enables adjusting product properties by modifying the production parameters. It can be concluded that biodegradable polymer dressings, releasing a propolis, may find potential application in the treatment of complicated wounds, as they may increase the effectiveness of treatment, as well as improve the patient’s life quality.
Highlights
Specialists all over the world struggle with the therapeutic problem of wound healing, which reduces many patients’ life quality
The use of polyurethane foils is recommended in the case of superficial and shallow wounds characterized by low exudation [3,23]
The analyzed research results indicate that development of completely biocompatible and biodegradable polymer dressings that release a substance with great therapeutic potential, propolis, would significantly contribute increasing the effectiveness of wound treatment, as well as improving the patient’s quality of life
Summary
Specialists all over the world struggle with the therapeutic problem of wound healing, which reduces many patients’ life quality. The inconvenience of the healing processes of complex wounds means that modern methods of treatment, which will be able to accelerate tissue regeneration and eliminate complications related to this process, are constantly being sought [1]. Due to the deteriorating health condition of the population, associated with the increasing prevalence of obesity and chronic diseases, such as circulatory failure and diabetes, the frequency of chronic wounds increases [2]. Chronic wounds are estimated to affect approximately 1–2% of the population in Europe and the United States [2]. Extensive burn wounds are important therapeutic problem, which may pose a threat to the patient’s life [3]
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