Nontraumatic Acute Subdural Hematoma Eight Days After COVID-19 Vaccination: A Case Report

Abstract

Nontraumatic acute subdural hematoma is rare, and no associations with the COVID-19 vaccine have been reported. This report presents the case of a 77-year-old woman who developed a nontraumatic acute subdural hematoma eight days after vaccination with the BNT162b2 COVID-19 vaccine. The patient regularly took 50 mg/day of clopidogrel and was diagnosed with severe acute subdural hematoma and brain herniation at admission. Although the BNT162b2 vaccine has not been determined as a risk factor, intracranial hemorrhage after its administration has been reported in Japan. Nontraumatic acute subdural hematoma may be included as an extremely rare adverse event of the BNT162b2 vaccine, but more data may be needed to confirm this.