Abstract
Hereditary factors have a strong influence on osteoarthritis (OA). The Wnt pathway is involved in bone and cartilage homeostasis. Hence, we hypothesized that allelic variations of WNT16 could influence the OA phenotype. We studied 509 Caucasian patients undergoing joint replacement due to severe primary OA. Radiographs were used to classify the OA as atrophic or hypertrophic. Two nonsynonymous polymorphisms of WNT16 (rs2707466 and rs2908004) were analyzed. The association between the genotypes and the OA phenotype was analyzed by logistic regression and adjusted for age and body mass index. A genotype-phenotype association was found in the sex-stratified analysis. Thus, there was a significant difference in the genotypic frequencies of rs2707466 between hypertrophic and atrophic hip OA in males (p=0.003), with overrepresentation of G alleles in the hypertrophic phenotype (OR 2.08; CI 1.28-3.38). An association in the same direction was observed between these alleles and the type of knee OA, with G alleles being more common in the hypertrophic than in atrophic knee phenotypes (p=0.008; OR 1.956, CI 1.19-3.19). Similar associations were found for the rs2908004 SNP, but it only reached statistical significance for knee OA (p=0.017; OR 0.92, CI 0.86-0.989). This is the first study attempting to explore the association of genetic variants with the OA phenotype. These data suggest the need to consider the OA phenotype in future genetic association studies of OA.
Highlights
Osteoporosis and osteoarthritis (OA) are the two most common musculoskeletal conditions, both primarily affecting older people, but the relationship between them is still unclear
In this, report we analyzed if the hip and knee OA phenotype is influenced by genetic variants of the Wnt ligand WNT16
The importance of WNT16 in the homeostasis of bone mass was confirmed by a Wnt16 cortical bones at the femur midshaft and reduced bone strength of both femur and tibia (19)
Summary
Osteoporosis and osteoarthritis (OA) are the two most common musculoskeletal conditions, both primarily affecting older people, but the relationship between them is still unclear. There was a significantly lower prevalence of osteophytes in patients with low phalangeal BMD and knee OA, whereas the prevalence of JSN was higher in the osteopenia and osteoporosis group than in subjects with normal BMD (10). Overall, these results suggest that the relation between BMD and OA could vary depending on the OA phenotype. In view of the effects of Wnt on both bone and cartilage homeostasis, and the emerging interactions between bone and cartilage in the osteoarthritis joints, which are likely different across OA phenotypes, the aim of this study was to test the hypothesis that common allelic variations of WNT16 could influence the OA phenotype
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
