Non-stick hemostasis hydrogels as dressings with bacterial barrier activity for cutaneous wound healing.

Abstract

Wound recovery is a complex process which is influenced by many factors. Therefore, dressings with multi-functions can greatly promote wound healing. In this study, a series of multifunctional PVA/HLC/SA composite hydrogels with air permeability, anti-protein absorption, bacterial barrier property and hemostasis activity were synthesized in the prospect of producing wound dressings by repeated freeze-thawing of poly (vinyl alcohol), Human-like collagen (HLC) and sodium alginate (SA) with Tween80 added as porogen. Infrared spectrometry (FT-IR) and scanning electron microscope (SEM) clarified its homogeneous porous and interconnected internal structures. In addition, the hydrogels were characterized statistically and in vivo full-thickness defects in rabbit was done to verify their effect on wound healing. Two of the hydrogels (gel 2 and gel 3) showed excellent water vapor transmission rate (2420.97 and 2798.09 g·cm-2·d-1)，their swelling ratio were 1427.44 and 2308.24% respectively, worked together with hemostasis property (hemostasis time of gel 2 and gel 3 were 30.55 and 17.33 s respectively), anti-protein absorption and bacterial barrier activity, greatly promoted the full-thickness wound healing in rabbit, wounds of the hydrogel dressing groups took only 10 days to heal, while the control groups need 13-15 days. In a whole, the results facilitate the use of provided hydrogel dressings as ideal wound dressings.