NONSTEROIDAL ANTI-INFLAMMATORY DRUGS AND HYPERTENSION – DOES AN EXEPTION CHANGE THE RULE?

Abstract

The aim of the study was to estimate the influence of nonsteroidal anti-inflammatory drugs (NSAIDs) on blood pressure, as well as the effects of these drugs on changing the response to applied antihypertensive treatment. The study included 661 patients, with elevated blood pressure, on regular antihypertensive treatment, of both sexes (51.1% female, 48.9% male) aged 30-89 years (65.86±13.5 years); 191 patients did not use NSAIDs (first group) and 470 patients regularly used these drugs (second group): (290 patients used acetylsalicylic acid (ASA) 100 mg per day, 108 patients used ASA in combination with acetic acid derivatives (AAD) 75-100mg per day or propionic acid derivatives (PAD) 400-800mg per day, and 72 patients AAD or PAD in the above doses). From the mean values of systolic blood pressure (SBP) and diastolic blood pressure (DBP), measured in one month intervals, during the 12 months, mean arterial pressure (MAP) was calculated. The mean values of blood pressure were 142.84±17.23mmHg for SBP, 85.08 ±11.16mmHg for DBP and 104.34±11.64mmHg for MAP. Value of SBP was not significantly different between the groups (I: 142.2±16.24mmHg; vs. II: 143.1±17.63mmHg, t=0.61, p>0.05), as well as MAP (I: 105.57±11.59mmHg; vs. II: 103.83±11.62mmHg, t=1.74, p>0.05). The value of diastolic blood pressure was significantly lower in patients who used NSAIDs (I: 87.25±11.3mmHg; vs. II: 84.19±11.0mmHg; t=3.22 p 0.05). Mean values of systolic blood pressure and mean arterial pressure in observed patients were above the target value, with no significant differences between the groups, while the diastolic blood pressure was in the normal range, but with considerably lower values in patients, who regularly used NSAIDs. Efficacy of antihypertensive treatment was independent of the applied type of NSAID.