Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are an important component of a multimodal pain management program in patients with rheumatic diseases in the perioperative period. NSAIDs have comprehensive analgesic, antiinflammatory, and antipyretic effects associated with blockade of the enzyme cyclooxygenase-2 and suppression of the synthesis of prostaglandins, one of the main mediators of pain and inflammation, which are synthesized in response to surgical tissue injury. NSAIDs can ease the suffering of patients in the pre- and postoperative periods and reduce the need for opioid analgesics and the frequency of adverse events (AE) caused by the latter. The choice of NSAIDs is largely determined by the risk of AE: gastrointestinal, cardiovascular and postoperative bleeding. The paper considers whether different NSAIDs can be chosen for patients with joint diseases during surgical treatment in terms of their efficacy and safety.
Highlights
Нестероидные противовоспалительные препараты (НПВП) – важный компонент мультимодальной программы обезболивания больных ревматическими заболеваниями в периоперационном периоде
Nonsteroidal anti-inflammatory drugs (NSAIDs) have comprehensive analgesic, antiinflammatory, and antipyretic effects associated with blockade of the enzyme cyclooxygenase-2 and suppression of the synthesis of prostaglandins, one of the main mediators of pain and inflammation, which are synthesized in response to surgical tissue injury
NSAIDs can ease the suffering of patients in the pre- and postoperative periods and reduce the need for opioid analgesics and the frequency of adverse events (AE) caused by the latter
Summary
Нестероидные противовоспалительные препараты (НПВП) – важный компонент мультимодальной программы обезболивания больных ревматическими заболеваниями в периоперационном периоде. Применение НПВП позволяет уменьшить страдания пациентов в до- и послеоперационном периоде, снизить потребность в опиоидных анальгетиках и частоту неблагоприятных реакций (НР), вызванных последними.
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