Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with a wide spectrum of side effects, including those involving renal, hepatic and haematological function and skin rashes. It is however the gastrointestinal effects of NSAIDs which are most serious and common. It is important to try to ascertain the true relationship between NSAID use and the clinically important gastrointestinal side effects and to develop startegies which might diminish this problem. In this review, we will discuss the pathophysiology of so-called 'NSAID gastropathy', review the epidemiology of NSAID-associated gastrointestinal side effects and examine clinical trial evidence that drugs might influence the ulcer healing rate and perhaps even prevent their development.
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