Nonsteroidal Anti-Inflammatory Drug Solid-State Microencapsulation on Green Activated Carbon - Mass Transfer and Host-Guest Interactions

Zvezdelina Lyubenova Yaneva

doi:10.15255/cabeq.2019.1656

Abstract

The present study investigated the drug-carrier capacity of green activated carbon derived from fruit stones by steam-gas activation (ACSTA) towards the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen (IBU), and assessed the host-guest interactions and mass transfer mechanism/s of the drug microencapsulation and in vitro release processes. The mass transfer studies outlined that the process of IBU encapsulation on ACSTA microparticles was predominantly controlled by intraparticle solid phase diffusion.

Highlights

The development of innovative controlled-release (CRS) systems for biologically active substances, which are becoming increasingly widely used in medicine, pharmaceutics and agriculture, is one of the top priority areas of scientific research in the field of medical chemistry over the last decade.[1]Microencapsulation of pharmaceutically active substances into appropriate carrier matrices ensures sustained or prolonged release of the drug; protection and stabilization of moisture, photo- and oxidation-sensitive biologically active compounds; prevention of incompatibility between drugs; predominant therapeutic action to specific activity sites.[2]
The aim of the present study was to investigate the drug-carrier capacity of green activated carbon derived from fruit stones by steam-gas activation (ACSTA) towards the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen, and to assess the host-guest interactions and mass transfer mechanism/s of the drug microencapsulation and in vitro release processes
The point of zero charge of ACSTA was experimentally determined by the solid phase addition method.[16]

Summary

Introduction

Microencapsulation of pharmaceutically active substances into appropriate carrier matrices ensures sustained or prolonged release of the drug; protection and stabilization of moisture-, photo- and oxidation-sensitive biologically active compounds; prevention of incompatibility between drugs; predominant therapeutic action to specific activity sites.[2] Adsorption as of drug molecules in porous micro-carrier particles is a readily adoptable microencapsulation technique for thermo-, photoliable drugs, and such, with limited solubility. Drug delivery systems (DDS) are based on a variety of carriers, such as polymers, modified natural and synthetic mineral matrices, micro- and nanomaterials, etc., applied alone or in different combinations.[3,4,5] The main qualitative indicators for assessing the effectiveness of CRS are the degree of incorporation and subsequent in vitro controlled release of the biologically active substance, which depend on the physicochemical and mechanical

Objectives

Methods

Results

Conclusion