Abstract
Hansenula polymorpha was cultivated in extended culture in an air lift tower loop reactor with the substrates enthanol and glucose, respectively. The spacial and time variations of process variables were simulated by a hybrid computer by means of a distributed parameter (dispersion) model, taking into account the spacial variations of pressure, volumetric mass transfer coefficient, dissolved oxygen concentration, oxygen gas phase mole fraction and gas velocity. The volumetric mass transfer coefficient at the gas entrance, k La E , its variation near the gas distributor, described by a coalescence factor, K ST , and the oxygen saturation constant, K O , were identified by quasi-steady-state methods. The kinetic parameters, maximum specific growth rate, μ max, and oxygen yield coeflicient, Y X/O , were identified during nonstationary simulation. The distributed parameter cultivation processes were simulated in a z (dimensionless longitudinal distance)— t (cultivation time)- The agreement between calculated and measured process variables is excellent.
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