Abstract
Nonspecific protein therapy recently celebrated its twentieth anniversary. Like many other new forms of medical treatment, it has had its ups and downs, its defenders and detractors. If during the past few years it has lost some of its former popularity, one need not be surprised, for this has been the fate of most new methods of therapy. Furthermore, whatever prestige protein therapy has lost through the excessive enthusiasm of its supporters is being regained, at least in part, by reason of a better understanding of the fundamental nature of the reactions that follow its use. In 1913 Fernando Torres,<sup>1</sup>a South American, reported successful results in the treatment of typhoid fever by giving typhoid vaccine intravenously and described the sharp reactions that followed its injection. Typhoid vaccine had been used previously to this in the treatment of typhoid, but the injections had always been given subcutaneously. In 1914 Dessy, Grapiolo and
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